Cf Research Paper

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* Hunt JF, Wang C, Ford RC 2013. Cystic fibrosis transmembrane conductance regulator (ABCC7) structure. Cold Spring Harb Perspect Med 10.1101/cshperspect. a009514 [PMC free article][PubMed][Cross Ref]

* Hwang T-C, Kirk KL 2013. The CFTR ion channel: Gating, regulation, and anion permeation. Cold Spring Harb Perspect Med

Defect in Zinc Supply Mechanism Affects Pathology of Intractable Pulmonary Diseases

Dec. 28, 2017 — Researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed ... read more


Chronic Bronchitis: New Insights Could Lead to First Diagnostic Test, Better Treatments

Sep. 6, 2017 — Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease ... read more


June 28, 2017 — Cystic fibrosis (CF) alters the structure of mucus produced in airway passages. In pigs affected by CF, mucus strands (made of MUC5B protein) are more tangled than normal, and the sheets of mucus ... read more


Bacteria from Cystic Fibrosis Patient Could Help Thwart Antibiotic-Resistant TB

June 14, 2017 — The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic -- produced by bacteria from the lung infection in a cystic fibrosis patient -- ... read more


Cystic Fibrosis Study Offers New Understanding of Silent Changes in Genes

May 18, 2017 — Researchers studying the root cause of cystic fibrosis have made a major advance in our understanding of silent gene changes with implications for the complexity of cystic ... read more


May 3, 2017 — Scientists have announced two major findings that further our understanding of how stem cells become organs: the ability to grow and purify the earliest lung progenitors that emerge from human stem ... read more


Apr. 27, 2017 — Substances produced by a harmful bacterium in the lungs of cystic fibrosis patients may enhance the growth of other bacteria that, in turn, inhibit the harmful bacterium's biofilm, according to ... read more


Apr. 12, 2017 — Cystic fibrosis currently has no cure, though a drug approved by the Food and Drug Administration treats the underlying cause of the disease. However, the drug's effectiveness for each ... read more


Novel Method for Generating Airway Cells from Stem Cells

Mar. 30, 2017 — Researchers have developed a new approach for growing and studying cells they hope one day will lead to curing lung diseases such as cystic fibrosis through 'personalized ... read more


Vitamins Could Help Treat Cystic Fibrosis, Research Finds

Mar. 27, 2017 — Researchers have discovered why antibiotics for treating people with cystic fibrosis are becoming less effective and how fat soluble vitamins might offer a viable ... read more


Mar. 27, 2017 — New research on bacteria that cause major problems for those with cystic fibrosis reveals clues as to how it proliferates for so long in the lungs and offers new ideas for treatments to ... read more


Potential of Stem Cell Therapy to Repair Lung Damage

Mar. 27, 2017 — A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical ... read more


Mar. 23, 2017 — In order to better understand how genetic mutations give rise to cystic fibrosis, researchers need to map the protein responsible for the disorder. The new structure has led to new insights on how ... read more


Mar. 23, 2017 — Scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can ... read more


Differences in Lifespan Between Canadians, Americans With Cystic Fibrosis, Study Finds

Mar. 13, 2017 — People with cystic fibrosis are living longer than ever before, but their lifespan is almost 10 years longer in Canada than in the United States, according to ... read more


Phage Therapy Shown to Kill Drug-Resistant Superbug

Mar. 13, 2017 — Phage therapy could offer a safe and effective alternative to antibiotics in the treatment of Cystic Fibrosis lung infections, researchers have demonstrated. Phages are viruses that kill bacteria but ... read more


Antibiotics Used to Treat Cystic Fibrosis Increases Risk of Permanent Hearing Loss

Feb. 25, 2017 — A powerful class of antibiotics provides life-saving relief for people with cystic fibrosis; however, a new study for the first time reveals the levels at which high cumulative dosages over time ... read more


New Potential Route to Treat Asthma Discovered

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Updated Cystic Fibrosis Diagnosis Guidelines Can Help in Diagnosis, Personalized Treatment

Jan. 31, 2017 — An international research group of 32 experts from nine countries has updated the guidelines for diagnosing the genetic disease cystic fibrosis. The researchers expect that these guidelines will ... read more


Bacterial 'Sabotage' Handicaps Ability to Resolve Devastating Lung Inflammation in Cystic Fibrosis

Dec. 13, 2016 — The chronic lung inflammation that is a hallmark of cystic fibrosis, has, for the first time, been linked to a new class of bacterial enzymes that hijack the patient’s immune response and prevent ... read more


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